H2 Tablet Studies

Study type: RCT

Implication: Anti-aging; DrinkHRW is an anti-aging agent that increases telomere length and improves DNA methylation. It also improves sleep quality and functioning in the elderly.

Author:

Zanini, et al.

Study title/link: https://www.sciencedirect.com/science/article/abs/pii/S0531556521003569?via%3Dihub/

Treatment Duration (days): 180

Year Published: 2021

Dose: 7.5 mg H2; HRW (15ppm of hydrogen) two time daily in the morning and the evening on empty stomach for 6 months.

Inclusion criteria:

1) age: 70 and over.

2) body mass index normal or overweight range.

3) no current acute disorders or major chronic dis-eases (e.g., cancer, neurodegenerative disorders, stroke, psychiatric diseases).

4) able to read and understand written consent form.

5) willing to take blood tests and other measurements.

6) willing to conusme assigned intervention.

number of subjects: 40

Outcome (positive):

1) Significant treatment vs time interaction for telomere length (p<0.05). Treatment group increased telomere length (from 0.99 ± 0.15 to 1.02 ± 0.26, up 4.1% at 6-month follow up), whereas the control group lost telomere length (from 0.92 ± 0.27 to 0.79 ± 0.15, down 11.1% at 6-month follow-up).
2) Brain choline and n-acetylaspartate levels increased in the left frontal gray matter, and creatine at the right parietal white matter. Brain n-acetylaspartate at the right parietal mesial grey matter (p<0.05)
3) Human growth hormone and serum IGF-1 levels tended to rise after HRW intervention.
4) LDL tended to decrease in HRW group, while triglycerides reduced in both groups
6) Serum malondialdehyde levels and ferric reducing ability of plasma strongly tended to decrease after HRW intervention (for 48.7% and 8.4%, respectively).
7) A significant change in improved chair stand performance in HRW group.
8) Quality of sleep improved in HRW group.
9) Significant interaction for pain domain of the quality of life profile with HRW vs placebo (p<0.05). VAS pain score
10) TET2 expression increased in both groups, but significantly more in HRW group (0.81 ± 0.52 at baseline to 1.13 ± 0.82)
11) All oxidative stress and inflammation markers tended to decrease.
12) Serum magnesium levels tended to increase in both groups, although marginally significantly more in the HRW group